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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus

Fig. 1

Impaired nucleotide excision repair in SLE patients. a Representative autoradiograms for the Southern blot analysis of melphalan-induced N-ras-specific DNA adducts. 0/0, no treatment. The kinetics of monoadducts (b) and total amounts of monoadducts expressed as AUC (c) in quiescent systemic lupus erythematosus (QSLE) and lupus nephritis (LN) patients as well as in 12 healthy controls (HC) are shown. The asterisks indicate significant differences (p < 0.05) between QSLE and LN patients. The experiments shown were based on a minimum of three independent repeats and the data reported are the mean ± SD of all subjects analyzed

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