Fig. 1
From: Can baseline serum microRNAs predict response to TNF-alpha inhibitors in rheumatoid arthritis?
miRNAs significantly differentially expressed in the discovery cohort. A large panel of miRNAs was measured using the OpenArray platform in serum of 40 ADA- and 40 ETN-treated patients. miRNAs showing significant differences (p < 0.05) between responders and non-responders were selected as potential predictors. Among all analyzed, four miRNAs were selected as potential predictors. Levels of miRNAs in each individual patient are shown as the fold changes (FCs) for ADA (a and b) and ETN (c and d). The geometric mean per group is shown and p values between responders and non-responders were calculated on the –ΔΔCrt using an independent sample t test. Several patients were excluded from the analysis because of low amplification quality (scores < 1.24): miR-99a (n = 16), miR-143 (n = 0), miR-23a (n = 4), and miR-197 (n = 2)