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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice

Fig. 1

Il21r KO mice were resistant to CIA. Mice were immunized with chicken CII emulsified in CFA and were boosted 3 weeks later. Incidence (a) and severity score (b) of CIA in WT mice (filled circle, n = 6) or Il21r KO mice (open square, n = 6). Clinical scores were calculated only in affected mice. Each point represents mean ± SEM. Statistical significance was analyzed by the log-rank test (a) or two-way ANOVA with repeated measures (b). p < 0.05, different between WT mice and Il21r KO mice. Data are representative of three independent experiments. c Histological examination of the hind limb from WT mice (left panel) or Il21r KO mice (right panel) 50 days after immunization. The samples were stained with hematoxylin and eosin (magnification: upper, ×40, lower, ×400). Il21r KO IL-21 receptor knockout, WT wild type

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