Fig. 6

Development of CIA in Rag2 KO mice reconstituted with WT and Il21r KO T cells and B cells. a Rag2 KO mice were transferred either with WT CD4 T cells and WT B cells (WT B cells), or with WT CD4 T cells and Il21r KO B cells (KO B cells). b Rag2 KO recipients were transferred either with WT CD4 T cells and WT B cells (WT T cells), or with Il21r KO CD4 T cells and WT B cells (KO T cells). The recipients were immunized with CII to induce CIA. Incidence (left) and severity score (right) of CIA are shown. Data are the sum of three independent experiments (n = 9). Clinical scores were calculated only in affected mice. Error bars represent mean ± SEM. Statistical significance was analyzed by the log-rank test (a, b left). KO knockout, WT wild type