Table 5 Association of changes in disease activity and plasma cytokines with changes in heart rate variability by univariate linear regression

Changes in disease activity

ΔBILAG

p = 0.081

β = −0.036

p = 0.605

β = −0.109

p = 0.168

β = −0.075

p = 0.119

β = 0.542

ΔSLEDAI

p  = 0.007

β = −0.023

p = 0.094

β = −0.144

p = 0.326

β = −0.023

p = 0.431

β = 0.116

ΔPGA

p = 0.209

β = −0.002

p = 0.704

β = −0.006

p = 0.067

β = −0.007

p = 0.174

β = 0.034

Cytokine changes

ΔsTNFRII

p = 0.824

β < −0.001

p = 0.789

β = 0.011

p = 0.168

β = −0.014

p  = 0.021

β = 0.150

ΔMIG

p = 0.453

β = −0.004

p = 0.963

β = −0.003

p = 0.176

β = −0.019

p  = 0.003

β = 0.253

ΔBLyS^a

p = 0.298

β = −0.002

p = 0.994

β < −0.001

p  = 0.036

β = −0.010

p = 0.057

β = 0.054

ΔIFN-α

p = 0.901

β < 0.001

p = 0.526

β = 0.037

p  = 0.004

β = −0.050

p  = 0.012

β = 0.356

ΔIL-1RA

p = 0.840

β = −0.003

p = 0.794

β = −0.044

p = 0.199

β = −0.055

p  = 0.023

β = 0.646

ΔIP-10

p = 0.671

β = −0.001

p = 0.679

β = 0.014

p = 0.945

β < −0.001

p = 0.895

β = 0.008

ΔSCF

p = 0.085

β = −0.004

p = 0.603

β = −0.011

p = 0.154

β = −0.008

p  = 0.001

β = 0.108

ΔIL-15

p = 0.764

β = −0.001

p = 0.471

β = 0.033

p  = 0.012

β = −0.026

p  = 0.010

β = 0.154