Fig. 2

Patients with high total lymphocyte counts (LC) or high frequency of plasmablasts (hiLOP) have higher disease activity. Baseline values of LC and plasmablasts in patients not achieving low disease activity (LDA) after 24 weeks (a). Baseline values of LC and plasmablasts in patients achieving LDA after 24 weeks (b). Dotted lines indicate the cutoff for baseline. Red and blue indicate the area for baseline hiLOP or low number of total lymphocyte counts and plasmablasts (loLAP), respectively. Change in disease activity score in 28 joints (DAS28) in patients with baseline loLAP and hiLOP (c). Statistical significance was assessed using the Mann-Whitney U test; ***P <0.001