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Table 2 Manometric parameters at baseline and after 4-week daily administration of 20 mg buspirone

From: The 5-HT1A receptor agonist buspirone improves esophageal motor function and symptoms in systemic sclerosis: a 4-week, open-label trial

  Baseline After buspirone p
Amplitude (mmHg) 16.6 ± 9.6 17.5 ± 9.6 0.163
Velocity (cm/sec) 3.7 ± 2.4 3.4 ± 1.9 0.701
Duration (sec) 2.6 ± 1.9 3.1 ± 2.3 0.668
LES resting pressure (mmHg) 7.7 ± 3.9 12.2 ± 4.6 0.00002
LES residual pressure (mmHg) 2.9 ± 1.9 3.2 ± 2.1 0.157
IRP (mmHg) 3.1 ± 2.3 3.5 ± 2.1 0.143
  1. LES lower esophageal sphincter, IRP integrated relaxation pressure