Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion

Table 2 Associations between Lequesne index and demographic, radiographic, and cardiovascular risk factors; anthropometric measurements; and inflammatory markers

	Category	Median or correlation (95 % CI)	p Value
Age		0.118 (−0.078, 0.313)	0.2090
KOA symptom duration (months)		−0.008 (−0.178, 0.176)	0.9345
Tobacco exposure	No	14.0 (13.0–15.0)	0.0608
Tobacco exposure	Yes	12.5 (7.0–15.0)
Physical exercise	Never	15.0 (13.0–16.0)	0.0401
	Occasional	14.0 (12.0–16.0)
	Regular	13.0 (10.0–14.0)
Radiographic severity (KL grade)	1	13.0 (9.0–15.0)	0.1721
	2	13.0 (12.0–15.0)
	3–4^a	14.0 (13.0–16.0)
DM	Yes	13.5 (11.0–18.0)	0.7480
DM	No	14.0 (13.0–15.0)	0.7480
DL	Yes	14.0 (12.0, 16.0)	0.8551
DL	No	14.0 (13.0–15.0)	0.8551
Obesity	Yes	14.0 (13.0–16.0)	0.0705
Obesity	No	13.0 (12.0–15.0)	0.0705
HT	Yes	14.0 (13.0–16.0)	0.0589
HT	No	13.0 (12.0–14.0)	0.0589
MetS	Yes	15.0 (13.0–16.0)	0.0722
MetS	No	13.0 (12.0–14.0)	0.0722
Crit MetS	0	12.5 (9.0–16.0)	0.1490
	1	14.0 (13.0–15.0)
	2	13.0 (11.0–14.0)
	3	15.5 (14.0–17.0)
	4	12.5 (10.0–18.0)
Percent body fat		0.243 (0.062–0.422)	0.0088
BMI		0.277 (0.097–0.435)	0.0027
Weight		0.249 (0.082–0.407)	0.0072
WC		0.404 (0.237–0.567)	<0.0001
HC		0.252 (0.078–0.412)	0.0065
WHR		0.221 (0.026–0.392)	0.0177
IL-6		0.146 (−0.045, 0.327)	0.1259
TNF-α		0.273 (0.078–0.448)	0.0057
hs-CRP		0.139 (−0.051, 0.320)	0.1429

Definition of abbreviations: KL Kellgren-Lawrence scale, DM Diabetes mellitus, DL Dyslipidemia, HT Hypertension, Crit MetS Number of individual criteria for metabolic syndrome, MetS Metabolic syndrome, BMI Body mass index, WC Waist circumference, HP Hip circumference, WHR Waist-to-hip ratio, IL-6 Interleukin 6, TNF-α Tumor necrosis factor-α, hs-CRP High-sensitivity C-reactive protein
Correlations for continuous variables, medians for groups and their corresponding 95 % confidence (95 % CI) are shown. The partial correlation coefficient after adjustment by measure round was used to assess associations for IL-6, TNF-α, and hs-CRP. Spearman’s correlation coefficient is shown for the rest of the continuous measures
^aBecause only four patients were classified as KL grade 4, KL grades 3 and 4 were combined in one category

ISSN: 1478-6362