Table 1 Characteristics of patients at the time of medication initiation
| Â | MTX | All TNFi | Anakinra | MTX with SJIA |
|---|---|---|---|---|
Number of patients | 3075 | 2713 | 247 | 160 |
Mean age, years (SD) | 9.0 (4.7) | 10.9 (4.7) | 9.4 (4.8) | 7.4 (4.6) |
Median age (IQR) | 9.0 (5.0–13.0) | 11.0 (7.0–15.0) | 9.0 (6.0–13.0) | 6.5 (3.0–11.0) |
Female sex, % | 66.0 | 68.3 | 64.4 | 56.9 |
Asthma, % | 8.2 | 6.1 | 6.5 | 7.5 |
Diabetes mellitus, % | 1.1 | 1.2 | 1.6 | 0.6 |
Psoriasis, % | 2.7 | 3.9 | 0 | 8.8 |
Baseline oral GC dose, % | ||||
 None | 67.1 | 57.5 | 22.3 | 40.0 |
 Low (<10 mg/day) | 24.1 | 29.7 | 33.6 | 26.3 |
 High (≥10 mg/day) | 8.8 | 12.9 | 44.1 | 33.8 |
MTX use on index date, % | N/A | 47.8 | 37.3 | N/A |
Cyclosporine use on index date, % | 0.4 | 1.0 | 3.6 | 6.9 |
Baseline infection, % | ||||
 None | 47.7 | 55.8 | 45.3 | 35.0 |
 Nonprimary hospitalized or outpatient | 49.6 | 42.1 | 47.4 | 54.4 |
 Primary hospitalized | 2.7 | 2.1 | 7.3 | 10.6 |