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Table 3 Associations between interleukin-6 (IL-6), matrix metalloproteinase-1 (MMP-1), MMP-3 and leptin in synovial fluid and suppressor of cytokine signaling-3 (SOCS-3) expression in cartilage from non-obese and obese patients with osteoarthritis

From: Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3

  

Non-obese, BMI <30 kg/m2

Obese, BMI >30 kg/m2

Dependent variable

Covariates

R 2 adjusted

P

R 2 adjusted

P

LN (SF MMP-1)

 

0.15

 

0.30

 
 

LN SOCS-3

 

0.818

 

0.007

 

LN (SF leptin)

 

0.884

 

0.023

LN (SF MMP-3)

 

0.03

 

0.27

 
 

LN SOCS-3

 

0.608

 

0.004

 

LN (SF leptin)

 

0.733

 

0.015

LN (SF IL-6)

 

−0.05

 

0.20

 
 

LN SOCS-3

 

0.945

 

0.003

 

LN (SF leptin)

 

0.808

 

0.466

  1. P values are calculated for covariates in analysis of variance modeling. The model is controlled for intergel variation in SOCS-3 expression levels. Analysis was performed in body mass index (BMI) subgroups. Natural logarithms (LN) were formed where appropriate. SF synovial fluid
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Arthritis Research & Therapy

ISSN: 1478-6362

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