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Table 3 Associations between interleukin-6 (IL-6), matrix metalloproteinase-1 (MMP-1), MMP-3 and leptin in synovial fluid and suppressor of cytokine signaling-3 (SOCS-3) expression in cartilage from non-obese and obese patients with osteoarthritis

From: Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3

   Non-obese, BMI <30 kg/m2 Obese, BMI >30 kg/m2
Dependent variable Covariates R 2 adjusted P R 2 adjusted P
LN (SF MMP-1)   0.15   0.30  
  LN SOCS-3   0.818   0.007
  LN (SF leptin)   0.884   0.023
LN (SF MMP-3)   0.03   0.27  
  LN SOCS-3   0.608   0.004
  LN (SF leptin)   0.733   0.015
LN (SF IL-6)   −0.05   0.20  
  LN SOCS-3   0.945   0.003
  LN (SF leptin)   0.808   0.466
  1. P values are calculated for covariates in analysis of variance modeling. The model is controlled for intergel variation in SOCS-3 expression levels. Analysis was performed in body mass index (BMI) subgroups. Natural logarithms (LN) were formed where appropriate. SF synovial fluid