Fig. 1

TLR10 gene variants. a Schematic representation of TLR10 protein that illustrates the position of the missense variants identified by next-generation sequencing. b Genotype distribution of the I473T variant in the independent cohort of 1493 healthy control subjects (HC) and 1201 patients with rheumatoid arthritis (RA). c TLR10 genotype frequencies in HapMap populations. The following population samples were included: CEU (Utah residents with Northern and Western European ancestry from the Centre d’etude du Polymorphisme Humain [CEPH] collection), HCB (Han Chinese in Beijing), JPT (Japanese in Tokyo, Japan), YRI (Yoruba in Ibadan, Nigeria), TSI (Toscani in Italy). LRR Leucine-rich repeats, TLR Toll-like receptor, TM Transmembrane domain, TIR Toll/interleukin-1 receptor domain