Fig. 2

Association of the I473T variant with disease severity in patients with RA. a Frequency of clinical parameters associated with severity in AA + AG and GG genotypes in a cohort of 453 patients. Differences were analyzed with the Fisher’s exact test. RF ⁺ Positive for (high levels of) rheumatoid factor, ACPA ⁺ Seropositive for antibodies to citrullinated protein antigens. b Disease severity associated to the G allele in 1201 patients with RA. The β value (regression coefficient), used to evaluate the effect of I473T variant (genetic risk), was estimated for a number of clinical findings. A positive regression coefficient means that the variant increases risk. Dotted lines indicate cutoff values. Clinical parameters were categorized as binary variables. Significance of the β value was determined by using the Wald test. Eccp/years Association with erosions in ACPA⁺ patients including the years of disease evolution; Eccp/years-women Association with erosions in ACPA⁺ female patients including the years of disease evolution, IFX-EULAR Association with response to infliximab (European League Against Rheumatism response criteria: moderate/good vs none), IFX-DAS28 Association with change in Disease Activity Score in 28 joints in patients treated with infliximab