A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis

Table 2 Sixteen allele variants of the TLR10 gene found by next-generation sequencing in control and rheumatoid arthritis populations

Reference SNP ID	Reference allele	Alternative allele	MAF	p Value	AA change	Functional class	SIFT prediction	SNPs3D prediction
rs10776482	A	G	0.29	0.2306	D809	Silent	nr	nr
rs4129008	C	T	0.01	0.5652	R799Q	Missense	−	−
rs4129009	T	C	0.271	0.1889	I775V	Missense	−	−
rs10776483	A	G	0.302	0.3296	H724	Silent	nr	nr
rs11466658	G	A	0.026	0.1599	R525W	Missense	−	−
rs11466657	A	G	0.089	0.04327	I473T	Missense	+	+
rs11096955	T	G	0.422	0.07296	I369L	Missense	−	−
rs11096956	C	A	0.292	0.3918	P344	Silent	nr	nr
rs11466653	A	G	0.026	0.5824	M326T	Missense	−	nr
rs11466652	T	C	0.13	0.1403	K303	Silent	nr	nr
rs11466651	C	T	0.026	0.5824	V298I	Missense	−	−
rs11096957	T	G	0.438	0.015	N241H	Missense	−	−
rs11466650	A	G	0.0005	0.137	L167P	Missense	+	+
rs11466649	C	A	0.026	0.5824	A163S	Missense	−	−
rs10856837	C	T	0.026	0.5824	T37	Silent	nr	nr
rs10856838	A	T	0.146	0.5813	I13	Silent	nr	nr

Abbreviations: MAF Minor allele frequency, + Damaging change, − No damaging change, nr No records, SNP Single-nucleotide polymorphism

ISSN: 1478-6362