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Demographics
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Age, mean (SD), years
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57.8 (13.9)
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Female gender, n (%)
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115 (74.2)
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Postmenopausal, n (%)
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70 (60.9)
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Age at menopause, mean (SD), years
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49.7 (4.2)
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Premature menopause, n (%)
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3 (4.3)
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Caucasian, n (%)
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148 (95.5)
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|
Body mass index, median (IQR), kg/m2
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25 (22–28)
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Current smoker, n (%)
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30 (19.4)
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Alcohol ≥3 units/day, n (%)
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3 (1.9)
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|
Comorbidities, mean number (SD)
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0.4 (0.6)
|
|
Previous fracture, n (%)
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7 (4.5)
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|
Parent fractured hip, n (%)
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15 (9.7)
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|
Calcium supplementation, n (%)
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2 (1.3)
|
|
Vitamin D supplementation, n (%)
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3 (1.9)
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Bisphosphonate use, n (%)
|
2 (1.3)
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|
Hormone replacement therapy, n (%)
|
5 (3.2)
|
|
Disease characteristics
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|
Symptom duration, median (IQR), weeks
|
12.9 (8.6–25.7)
|
|
1987 American College of Rheumatology criteria fulfilled, n (%)
|
107 (69)
|
|
Disease activity score in 28 joints, mean (SD)
|
4.42 (1.28)
|
|
Swollen joint count in 28 joints, median (IQR)
|
5 (3–8)
|
|
Tender joint count in 28 joints, median (IQR)
|
6 (3–10)
|
|
Ultrasound grayscale score, median (IQR), 0–36 score
|
5 (2–9)
|
|
Ultrasound power Doppler score, median (IQR), 0–36 score
|
2 (0–7)
|
|
Erythrocyte sedimentation rate, median (IQR), mm/1 h
|
17 (8–33)
|
|
C-reactive protein, median (IQR), mg/dlL
|
0.7 (0.3–1.7)
|
|
Rheumatoid factor-positive, n (%)
|
67 (43.2)
|
|
Rheumatoid factor titres in positive patients, median (IQR), U/mL
|
82 (34.8–195.8)
|
|
Anti-citrullinated protein antibody-positive, n (%)
|
66 (42.6)
|
|
Anti-citrullinated protein antibody titres in positive patients, median (IQR), U/mL
|
237 (77.5–445.8)
|
|
Erosion Sharp–van der Heijde Score ≥1, n (%) (n = 152)
|
32 (21.1)
|
|
Total Sharp–van der Heijde Score, median (IQR), 0–448 scale (n = 152)
|
3 (1.25–7.5)
|
|
Health Assessment Questionnaire, median (IQR), 0–3 scale
|
1 (0.438–1.438)
|
|
DXA
|
|
Spine L1–L4 (n = 153)
| |
|
Bone mineral density, mean (SD), g/cm2
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0.936 (0.157)
|
|
Z score, mean (SD)
|
0.013 (1.315)
|
|
Z score ≤ -1, n (%)
|
39 (25.5)
|
|
- men
|
13 (33.3)
|
|
- premenopausal women
|
13 (28.9)
|
|
- postmenopausal women
|
13 (18.1)
|
|
Total hip (n = 155)
|
|
BMD, mean (SD), g/cm2
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0.728 (0.132)
|
|
Z score, mean (SD)
|
-0.128 (1.027)
|
|
Z score ≤ -1, n (%)
|
30 (19.4)
|
|
- men
|
7 (17.5)
|
|
- premenopausal women
|
12 (26.7)
|
|
- postmenopausal women
|
11 (15.7)
|
|
Either spine L1–L4 or total hip (n = 153)
| |
|
Z score ≤1, n (%)
|
54 (35.3)
|
|
- men
|
16 (41)
|
|
- premenopausal women
|
19 (42.2)
|
|
- postmenopausal women
|
19 (27.5)
|
