Fig. 2From: A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritisComparison of the most highly discriminative urinary analytes to several previously proposed biomarkers. Scatter plots showing the normalized concentration of selected urinary proteins in healthy controls (HC; n = 24, open circles) and SLE patients with active non-LN (ANLN; n = 25, closed circles) or active LN (ALN; n = 60, closed triangles). Urinary concentrations were corrected for creatinine to normalize for osmolality. Units for all graphs are pg/μmol, except PF4 and TWEAK which are in ng/μmol. a Urinary analytes that demonstrated >3 log2 fold-difference between ANLN and ALN. b Previously proposed urinary biomarkers. For all graphs each symbol represents the determination from a single individual, with the mean value for each group indicated by a horizontal line. Fold-differences and statistical comparisons for the analytes are shown in Table 2. c Correlation between the urinary analytes that demonstrated >3 log2 fold-difference between ANLN and ALN and that showed the strongest association with albuminuria, estimated glomerular filtration rate (GFR), or Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI). Lines indicate linear regression curves. Spearman’s correlation coefficients are shownBack to article page