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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis

Fig. 2

Comparison of the most highly discriminative urinary analytes to several previously proposed biomarkers. Scatter plots showing the normalized concentration of selected urinary proteins in healthy controls (HC; n = 24, open circles) and SLE patients with active non-LN (ANLN; n = 25, closed circles) or active LN (ALN; n = 60, closed triangles). Urinary concentrations were corrected for creatinine to normalize for osmolality. Units for all graphs are pg/μmol, except PF4 and TWEAK which are in ng/μmol. a Urinary analytes that demonstrated >3 log2 fold-difference between ANLN and ALN. b Previously proposed urinary biomarkers. For all graphs each symbol represents the determination from a single individual, with the mean value for each group indicated by a horizontal line. Fold-differences and statistical comparisons for the analytes are shown in Table 2. c Correlation between the urinary analytes that demonstrated >3 log2 fold-difference between ANLN and ALN and that showed the strongest association with albuminuria, estimated glomerular filtration rate (GFR), or Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI). Lines indicate linear regression curves. Spearman’s correlation coefficients are shown

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