Fig. 3

Urinary proteins that discriminate between proliferative and non-proliferative/chronic lesions on renal biopsy. Scatter plots showing the normalized concentration of selected urinary proteins in SLE patients with proliferative LN (Prol; Class III and IV (A) or (A/C), n = 38, closed triangles) and non-proliferative or chronic lesions (NPC; Class I, II, V, or VI, and Class III or IV (C), n = 22, open triangles) on renal biopsy as compared to active SLE patients without LN (NLN; n = 25, closed circles). Units for all analytes are pg/μmol, except vWF and PF4 which are in ng/μmol. a Plots for the eight urinary proteins that discriminated between proliferative and NPC lesions on renal biopsy. In the two columns on the right of each plot the NPC results have been subdivided into chronic class III/IV (III/IV(C)) and other non-proliferative/chronic lesions (NP). b Plots for three representative urinary proteins that did not discriminate between proliferative and non-proliferative or chronic lesions on renal biopsy, demonstrating their ability to discriminate between non-proliferative/chronic lesions and active non-LN. For all graphs, each symbol represents the determination from a single individual, with the mean value for each group indicated by a horizontal line. Significance levels were determined by Mann-Whitney non-parametric testing and have been corrected for multiple testing. Only the differences between proliferative and non-proliferative/chronic lesions, and non-proliferative/chronic lesions and active non-LN for each analyte are shown. In graphs in panel (a), significant differences between active proliferative and chronic class III/IV lesions are also indicated, and represent uncorrected p values. *p < 0.05, **p <0.005, NS not significant