A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis

Table 3 Results of the ROC analysis for diagnosis of ALN

Analyte	Sensitivity	Specificity	AUC	Best cut-off
Adiponectin	0.77	0.92	0.88	1.86 × 10³
PAI-1	0.82	0.92	0.90	4.47 × 10^–1
IL-15	0.70	0.96	0.84	3.05 × 10^–1
PF4	0.93	0.76	0.90	2.44 × 10^–3
TIMP-1	0.90	0.84	0.91	1.26 × 10²
sVCAM	0.83	0.76	0.81	5.29 × 10²
MCP-1	0.75	0.84	0.81	1.25 × 10²
TWEAK	0.47	0.96	0.73	2.73 × 10^–2
NGAL	0.85	0.48	0.69	3.35 × 10³
Albumin	0.95	0.84	0.93	4.90 × 10⁶
Creatinine	0.58	0.96	0.76	8.05 × 10¹
C3	0.57	0.72	0.57	7.60 × 10^–1
anti-dsDNA	0.30	0.80	0.48	1.00 × 10²

ALN active lupus with lupus nephritis, AUC area under the curve, ROC receiver operating characteristic

ISSN: 1478-6362