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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

Fig. 1

Serum S100A8/A9 levels correlate with macroscopic score for joint swelling. a Starting at week 6, IL-1Ra–/– mice (n = 26) developed a spontaneous and highly heterogeneous joint swelling in the hind paws (combined score of left and right paw). b At end-point (week 15), serum levels of S100A8/A9 correlated to the combined macroscopic score for joint swelling. c Contrastingly, serum levels of the pro-inflammatory cytokines IL-1β, IL-6, and TNF did not correlate with the combined macroscopic score for joint swelling at week 15. IL interleukin, IL-1Ra interleukin-1 receptor antagonist, TNF tumor necrosis factor

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Arthritis Research & Therapy

ISSN: 1478-6362

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