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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: S100A8/A9, a potent serum and molecular imaging biomarker for synovial inflammation and joint destruction in seronegative experimental arthritis

Fig. 4

Serum S100A8/A9 levels correlate with histological parameters of bone erosion and cartilage damage. a Increased bone erosion (*) was observed in arthritic IL-1Ra–/– mice, which correlated with serum levels of S100A8/A9. bd Several parameters for cartilage damage were investigated. Proteoglycan depletion (b), chondrocyte death (c, arrow heads), and cartilage erosion (d, black line) were increased in arthritic IL-1Ra–/– mice, and all these parameters correlated to serum levels of S100A8/A9. Nav navicular, PG proteoglycan, Ta talus, Ti tibia

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