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Table 3 Correlation between C4d, C3bBbP, sTCC and other biomarkers in the recent injury group

From: The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis

Biomarkers n C4d C3bBbP sTCC
IL-1β 112 0.397 (<0.001) 0.232 (0.014) 0.297 (0.001)
IL-6 112 0.364 (<0.001) 0.235 (0.013) 0.268 (0.004)
IL-8 112 0.355 (<0.001) 0.183 (0.054) 0.372 (<0.001)
TNF-α 112 0.547 (<0.001) 0.317 (0.001) 0.391 (<0.001)
sGAG 181 0.108 (0.148) 0.092 (0.218) 0.132 (0.077)
ARGS 111 −0.023 (0.811) −0.113 (0.238) 0.176 (0.065)
COMP 112 −0.019 (0.845) −0.149 (0.116) −0.057(0.549)
C2C 164 −0.181 (0.020) −0.101 (0.197) −0.085 (0.279)
Osteocalcin 112 0.265 (0.005) 0.192 (0.043) 0.016 (0.871)
SPARC 112 0.476 (<0.001) 0.221 (0.019) 0.401 (<0.001)
Osteopontin 112 0.167 (0.079) 0.098 (0.302) 0.165 (0.083)
  1. Abbreviations: IL Interleukin, TNF-α Tumour necrosis factor α, sGAG Sulfated glycosaminoglycan, ARGS ARGS-aggrecan, COMP Cartilage oligomeric matrix protein, C2C Type II collagen epitope, SPARC Secreted protein acidic and rich in cysteine, sTCC Soluble terminal complement complex
  2. Correlation using Spearman rho (r s), between synovial fluid biomarkers was analysed in samples from the recent injury group (0–83 days after injury). Significant correlations (p < 0.05) are shown in boldface type. The table shows r s with p values in brackets. References to biomarkers: cytokines, ARGS, sGAG, osteocalcin, SPARC, osteopontin [14], COMP [19], C2C [23]