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Table 4 C4d, C3bBbP, sTCC concentrations in the recent injury group in relation to structural features

From: The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis

  Any OC fracture (n = 67) vs. No OC fracture (n = 31) vs. OC fracture with disrupted cortical bone (n = 38) vs. OC fracture without disrupted cortical bone (n = 29)
Mean (95 % CI) p value Mean (95 % CI) p value Mean (95 % CI) p value Mean (95 % CI)
C4d 38.90 (32.01–47.29) 0.014 23.92 (15.17–37.70) 0.004 45.42 (33.95–60.79) 0.025 31.76 (25.00–40.35)
C3bBbP 235.61 (203.19–273.15) 0.478 213.60 (162.33–281.06) 0.612 237.30 (195.79–287.61) 0.637 233.35 (182.64–298.19)
sTCC 12.81 (11.35–14.47) 0.004 9.27 (7.20–11.94) <0.001 14.26 (12.20–16.68) 0.056 11.13 (9.20–13.46)
  ACL injury
(n = 60)
vs. No ACL injury (n = 38)     
  Mean (95 % CI) p value Mean (95 % CI)     
C4d 34.34 (28.39–41.52) 0.418 31.86 (20.87–48.66)     
C3bBbP 231.42 (198.93–269.28) 0.417 223.67 (174.62–286.48)     
sTCC 11.53 (10.26–12.97) 0.885 11.61 (9.08–14.85)     
  Meniscal tear (n = 43) vs. No meniscal tear (n = 55)     
  Mean (95 % CI) p value Mean (95 % CI)     
C4d 29.36 (21.57–39.98) 0.565 36.86 (28.42–47.80)     
C3bBbP 204.27 (172.78–241.49) 0.399 249.23 (205.21–302.69)     
sTCC 9.91 (8.46–11.62) 0.013 13.05 (11.08–15.37)     
  1. Abbreviations: ACL Anterior cruciate ligament, OC Osteochondral, sTCC Soluble terminal complement complex
  2. Magnetic resonance imaging results were available for a subfraction of the recent injury group (n = 98). Between-groups statistical testing was performed using analysis of covariance of log10-transformed concentrations with adjustment for days between the injury and synovial fluid aspiration, age at injury, and sex. Significant differences (p < 0.05) are shown in boldface type. Concentrations in complement activation units are presented as linear data as means with 95 % CI in brackets