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Table 4 C4d, C3bBbP, sTCC concentrations in the recent injury group in relation to structural features

From: The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis

 

Any OC fracture (n = 67)

vs.

No OC fracture (n = 31)

vs.

OC fracture with disrupted cortical bone (n = 38)

vs.

OC fracture without disrupted cortical bone (n = 29)

Mean (95 % CI)

p value

Mean (95 % CI)

p value

Mean (95 % CI)

p value

Mean (95 % CI)

C4d

38.90 (32.01–47.29)

0.014

23.92 (15.17–37.70)

0.004

45.42 (33.95–60.79)

0.025

31.76 (25.00–40.35)

C3bBbP

235.61 (203.19–273.15)

0.478

213.60 (162.33–281.06)

0.612

237.30 (195.79–287.61)

0.637

233.35 (182.64–298.19)

sTCC

12.81 (11.35–14.47)

0.004

9.27 (7.20–11.94)

<0.001

14.26 (12.20–16.68)

0.056

11.13 (9.20–13.46)

 

ACL injury

(n = 60)

vs.

No ACL injury (n = 38)

    
 

Mean (95 % CI)

p value

Mean (95 % CI)

    

C4d

34.34 (28.39–41.52)

0.418

31.86 (20.87–48.66)

    

C3bBbP

231.42 (198.93–269.28)

0.417

223.67 (174.62–286.48)

    

sTCC

11.53 (10.26–12.97)

0.885

11.61 (9.08–14.85)

    
 

Meniscal tear (n = 43)

vs.

No meniscal tear (n = 55)

    
 

Mean (95 % CI)

p value

Mean (95 % CI)

    

C4d

29.36 (21.57–39.98)

0.565

36.86 (28.42–47.80)

    

C3bBbP

204.27 (172.78–241.49)

0.399

249.23 (205.21–302.69)

    

sTCC

9.91 (8.46–11.62)

0.013

13.05 (11.08–15.37)

    
  1. Abbreviations: ACL Anterior cruciate ligament, OC Osteochondral, sTCC Soluble terminal complement complex
  2. Magnetic resonance imaging results were available for a subfraction of the recent injury group (n = 98). Between-groups statistical testing was performed using analysis of covariance of log10-transformed concentrations with adjustment for days between the injury and synovial fluid aspiration, age at injury, and sex. Significant differences (p < 0.05) are shown in boldface type. Concentrations in complement activation units are presented as linear data as means with 95 % CI in brackets