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Table 1 Baseline characteristics of patients between treatment groups

From: Efficacy of glucosamine plus diacerein versus monotherapy of glucosamine: a double-blind, parallel randomized clinical trial

Characteristics Glucosamine sulfate plus diacerein (n = 74) Glucosamine sulfate plus placebo (n = 74)
Age, years, mean (SD) 58.8 (6.6) 61.2 (7.3)
Sex, %
 Male 11 (14.9) 14 (18.9)
 Female 63 (85.1) 60 (81.1)
BMI, kg/m2, mean (SD) 28.9 (5.3) 27.2 (4.2)
Knee symptoms, n (%)
 Warmth
  Yes 22 (30.14) 24 (32.43)
  No 51 (69.86) 50 (67.57)
 Stiffness
  Yes 39 (52.7) 33 (44.6)
  No 35 (47.3) 41 (55.4)
Duration of symptoms before enrollment, months, median (range) 12 (2–120) 12 (2–120)
Drug allergy, n (%)
 Yes 15 (20.3) 15 (20.3)
 No 59 (79.7) 59 (79.7)
Underlying disease, n (%)
 Diabetes
  Yes 8 (10.8) 13 (17.6)
  No 65 (89.2) 61 (82.4)
 Hypertension
  Yes 40 (54.1) 34 (45.9)
  No 34 (45.9) 40 (54.1)
 Dyspepsia
  Yes 8 (11.76) 7 (9.86)
  No 60 (88.24) 64 (90.14)
 Other disease
  Yes 34 (45.9) 32 (43.2)
  No 40 (54.1) 42 (56.8)
 Defecation
  Normal 59 (79.7) 54 (73)
  Abnormal 15 (20.3) 20 (27)
 Smoking
  Yes 1 (1.4) 3 (4)
  No 73 (98.6) 71 (96)
 Alcohol drinking
  Yes 7 (9.5) 3 (4)
  No 67 (90.5) 71 (96)
 Family history of OA knee
  Yes 25 (33.8) 31 (41.9)
  No 49 (66.2) 43 (58.1)
 Quadriceps exercises
  Yes 46 (62.2) 48 (64.9)
  No 28 (37.8) 26 (35.1)
Kellgren-Lawrence grade 2, % 81.1 76.4
VAS pain score, mean (SD) 5.01 (2.55) 5.05 (2.61)
WOMAC score
 Total, mean (SD) 82.3 (47.3) 81.4 (44.1)
 Pain, mean (SD) 21.3 (11.8) 21.1 (12.3)
 Stiffness, median (range) 6.5 (0–20) 4.5 (0–20)
 Function, mean (SD) 54.2 (32.7) 54.4 (29.3)
Joint space width, mm, mean (SD)
 Medial minimal width, right 2.98 (0.82) 2.82 (0.84)
 Lateral minimal width, right 4.25 (1.28) 4.32 (1.12)
 Medial minimal width, left 2.83 (0.84) 2.90 (0.78)
 Lateral minimal width, left 4.35 (1.10) 4.28 (1.15)
  1. Abbreviations: BMI Body mass index, OA Osteoarthritis, VAS Visual analogue scale, WOMAC Western Ontario and McMaster Universities Osteoarthritis Index