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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease

Fig. 2

Heterogeneous capacity of rheumatoid arthritis (RA) synovial fluid (RASF) samples to stimulate cytokine production and respond to TLR4 blockade. RASF samples from patients (Pat) were classified as NI-0101 responders if NI-0101 was able to block (partially or totally) RASF-induced IL-6 production from RA monocytes. Others were classified as NI-0101 non-responders. a, b Representative examples of RASF from non-responders (Pat#13, Pat#35) and from responders (Pat#27, Pat#18). Of the 40 RASF samples tested, 20 were classified as NI-0101 responders (50 %) and 20 as NI-0101 non-responders (50 %). c, d Mean levels of IL-6 in RASF NI-0101 responder and non-responder RASF samples. IL-6 is presented as normalized values with IL-6 levels induced by RASF arbitrarily set as 100 % induction. RASF samples that were unable to induce IL-6 from RA monocytes but were impacted upon by NI-0101 are excluded from the non-responder group. The Mann-Whitney U test was performed to test for differences among groups; ***p < 0.001, *p < 0.05

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