Table 1 The sensitivity and specificity of individual citrullinated peptides and their combinations in predicting NI-0101 response
ACPA-positive RASF | ACPA-negative and ACPA-positive RASF | |||
|---|---|---|---|---|
ACPA-related biomarkers | Sensitivity | Specificity | Sensitivity | Specificity |
ACPA (CCP2) | N/A | N/A | 85 % | 75 % |
cFbα-peptide (#1) | 94 % | 80 % | 85 % | 95 % |
cFbβ-peptide (#2) | 65 % | 100 % | 55 % | 100 % |
cH2A-peptide (#3) | 70 % | 80 % | 60 % | 95 % |
(#1) + (#2) | 94 % | 80 % | 85 % | 95 % |
(#1) + (#3) | 100 % | 80 % | 90 % | 95 % |
(#2) + (#3) | 88 % | 80 % | 75 % | 95 % |
(#1) + (#2) + (#3) | 100 % | 80 % | 90 % | 95 % |