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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium

Fig. 2

The binding of ultra-small superparamagnetic particles of iron oxide (USPIO)-P258 and of USPIO-poly(ethylene glycol) PEG (USPIO-PEG) to Jurkat cells stimulated by 5-Aza-2′-deoxycytidine (ADC), or not stimulated (NS), is presented as Fe concentration (left histogram). The binding of these contrast agents to ADC-stimulated Jurkat cells is also exemplified by the magnetic resonance image (right upper column); control represents Jurkat cells not incubated with contrast agents and included in gelatin. USPIO-P258 and USPIO-PEG bound to ADC-stimulated Jurkat cells were detected by immunofluorescence with anti-PEG antibody (green fluorescence) and co-localized with anti-IL-7 receptor (anti-IL-7R) antibody (red fluorescence) on the same cells. *p < 0.05, **p < 0.01 for ADC vs. NS; §§ p < 0.01 for USPIO-P258/ADC vs. USPIO-PEG/ADC; ## p < 0.01 for USPIO-P258/NS vs. USPIO-PEG/NS

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