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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium

Fig. 3

Color overlay of rapid acquisition with relaxation enhancement (RARE) magnetic resonance images (spatial resolution = 156 × 90 μm) of the hind limbs of mice with collagen-induced arthritis (CIA) (a) or healthy mice (b) injected with either ultra-small superparamagnetic particles of iron oxide (USPIO)-P258 or USPIO-poly(ethylene glycol) (USPIO-PEG) in pre-contrast and about 2 h post contrast. Arrowheads indicate the hind paw; arrow indicates the knee. Color overlays are related to the negative signal enhancement, which is observed by the shift of colors from blue to black; on the post-USPIO-P258 image of the CIA mouse, arrowheads and arrow indicate the negatively contrasted constituents of the hind limb. C calcaneus, CB coxal bones, K knee, P paw, Ph phalanx, Mt metatarsal bones, T tibia

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