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Table 1 Alignment of peptides expressed by clones 29, 36 and 37 with relevant protein sequences (identified with Swiss-Prot accession numbers), where the homologous amino acids are shown

From: Screening for peptides targeted to IL-7Rα for molecular imaging of rheumatoid arthritis synovium

Peptide (IL-7 IC50) Homology
C36/R2: C-PHPQRPA-C (2.41 × 10−6 M) Suppressor of cytokine signaling 7 (O14512): 92 PQPQPPA 98; Signal transducer and activator of transcription 4 (Q14765): 327 HPQRP 331; Fibronectin (P02751): 298 PHPQPP 303; Serine/threonine-protein kinase ICK (Q9UPZ9): 591 PHPGRP 596
C29/R3: C-KIMKSMP-C (3.98 × 10−8 M) Fibronectin type III domain-containing protein 3B (Q53EP0): 1169MKSM 1172; Serine/threonine-protein kinase ATR (Q13535): 75 IMKSSP 80; Serine/threonine-protein kinase mTOR (P42345): 1701 MKNM---KILKNM 1998; Interferon omega-1 (P05000): 171 IMKSL175; Transmembrane and immunoglobulin domain-containing protein 1 (Q6UXZ0): 245 KIMK 248; Tumor necrosis factor alpha-induced protein 8-like protein 3 (Q5GJ75): 164 KIMK 167; Tyrosine-protein kinase STYK1 (Q6J9G0): 343 KIMK---IMKS 361; Frizzled-9 (O00144): 429 KIMK 432; Cadherin-16 (O75309): 777 MKGMP 781
C37/R2: C-ASACPPH-C (5.10 × 10−6 M) Tumor necrosis factor receptor superfamily member 27 (Q9HAV5): 43 ACPP 46; Cadherin EGF LAG seven-pass G-type receptor 3 (Q9NYQ7): 1955 CPPH 1958; Rho GTPase-activating protein 29 (Q52LW3): 1212 ASACP 1216; Serine/threonine-protein kinase WNK2 (Q9Y3S1): 688 APACPP---ASPCP---PP 1741; Serine/threonine-protein kinase D2 (Q9BZL6): 860 ACPPQ864; Phosphoserine phosphatase (P78330): 186 ACPP 189; Laminin subunit alpha-1 (P25391): 276 ASSCP---CPPH 1019; Ephrin type-A receptor 3 (P29320): 290 CPPH 293; Ephrin type-A receptor 4 (P54764): 293 CPPH 296; Ephrin type-A receptor 5 (P54756): 322 CPPH 325; Ephrin type-A receptor 6 (Q9UF33): 296 CPPH 299; Ephrin type-A receptor 8 (P29322): 293 CPPH 296
  1. The aligned amino acids are highlighted as bold. The half maximal inhibitory concentration (IC50) values of IL-7 in competition with the same phage clones are also shown