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Table 1 Intersect of significantly increased IgG-autoantibodies in patients with established RA (cohort A) and early RA (cohort B)

From: Sequential high-content profiling of the IgG-autoantibody repertoire reveals novel antigens in rheumatoid arthritis

Antigen   Cohort A Cohort B
symbol Name Gene ID P FC S P FC S
DCTN1 Dynactin 1 1639 0.026 1.5 14 0.001 1.5 19
GNPTG N-acetylglucosamine-1-phosphate transferase 84572 0.021 1.2 17 0.001 1.3 13
HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1-like 2 144983 0.020 1.3 22 0.000 1.3 34
ITFG3 Integrin alpha FG-GAP repeat containing 3 83986 0.048 1.1 19 0.014 1.1 23
APOA4 Apolipoprotein A-IV 337 0.025 1.1 35 0.001 1.2 11
CCDC136 Coiled-coil domain containing 136 64753 0.039 2.2 14 0.031 1.7 2
CKAP4 Cytoskeleton-associated protein 4 10970 0.027 1.2 22 0.000 1.3 28
CLCN2 Chloride channel 2 1181 0.037 1.3 19 0.016 1.2 10
DMTF1 Cyclin D binding myb-like transcription factor 1 9988 0.047 1.3 22 0.022 1.3 11
FAM59B Family with sequence similarity 59. member B 150946 0.047 1.9 18 0.000 1.5 15
IGFBP2 Insulin-like growth factor binding protein 3485 0.015 1.2 19 0.000 1.5 13
TMCO7 Transmembrane and coiled-coil domains 7 79613 0.009 1.1 21 0.000 1.5 20
USP48 Ubiquitin specific peptidase 48 84196 0.001 2.7 18 0.034 1.7 11
VIM Vimentin 7431 0.022 1.3 19 0.000 1.7 38
ZFAND2B Zinc finger. AN1-type domain 2B 130617 0.034 1.2 18 0.002 1.3 22
ATP6V1A ATPase. H+ transporting. lysosomal 70 kDa. V1 subunit A 523 0.048 1.2 21 0.042 1.3 11
GSN Gelsolin 2934 0.008 1.4 26 0.001 1.4 12
GSPT2 G1 to S phase transition 2 23708 0.045 1.2 14 0.043 1.3 8
HSBP1 Heat shock factor binding protein 1 3281 0.021 1.2 25 0.002 1.3 19
NONO Non-POU domain containing. octamer-binding 4841 0.010 1.4 21 0.016 1.3 17
PRAP1 Proline-rich acidic protein 1 118471 0.030 1.3 14 0.035 1.6 9
YES1 YES proto-oncogene 1. Src family tyrosine kinase 6714 0.032 1.1 28 0.010 1.2 13
SSB Sjogren syndrome antigen B (autoantigen La) 6741 0.009 1.4 15 0.042 1.1 17
  1. Cohort A: established rheumatoid arthritis (RA) (n = 72). Cohort B: early RA (n = 116). P is p value for fold change (FC) and sensitivity (S) at 90 % specificity compared to matched healthy controls, according to the Mann-Whitney test