Table 2 Intersect of significantly increased IgG-autoantibodies in independent cohorts of patients with seronegative RA (cohorts B- and C)
Antigen | Cohort B- | Cohort C | ||||||
|---|---|---|---|---|---|---|---|---|
Symbol | Name | Gene ID | P | FC | S | P | FC | S |
GNPTG | N-acetylglucosamine-1-phosphate transferase. gamma subunit | 84572 | 0.001 | 1.4 | 16 | 0.04 | 1.1 | 10 |
HNRNPA1 | Heterogeneous nuclear ribonucleoprotein A1-like 2 | 144983 | 0.000 | 1.4 | 41 | 0.000 | 1.1 | 24 |
ACTB | Actin beta | 60 | 0.004 | 1.1 | 20 | 0.000 | 1.2 | 27 |
HSPD1 | Heat shock 60 kDa protein 1 (chaperonin) | 3329 | 0.008 | 1.6 | 14 | 0.002 | 1.8 | 17 |
PER1 | Period homolog 1 | 5187 | 0.000 | 2.2 | 24 | 0.001 | 1.5 | 13 |
SMARCD3 | SWI/SNF related. matrix associated. actin dependent regulator of Chromatin. subfamily d. member 3 | 6604 | 0.016 | 1.3 | 14 | 0.016 | 1.1 | 14 |
SMYD2 | SET and MYND domain containing 2 | 56950 | 0.007 | 1.6 | 10 | 0.05 | 1.4 | 5 |
IGFBP2 | Insulin-like growth factor binding protein 2. 36 kDa | 3485 | 0.003 | 1.5 | 16 | 0.03 | 1.1 | 14 |
KLKB1 | Kallikrein B. plasma (Fletcher factor) 1 | 3818 | 0.03 | 1.2 | 10 | 0.03 | 1.2 | 13 |
GON4L | Gon-4-like (C. elegans) | 54856 | 0.01 | 1.2 | 12 | 0.02 | 1.1 | 15 |
CHMP5 | Chromatin modifying protein 5 | 51510 | 0.03 | 1.5 | 12 | 0.004 | 1.3 | 14 |
DHX15 | DEAH (Asp-Glu-Ala-His) box polypeptide 15 | 1665 | 0.007 | 1.5 | 12 | 0.03 | 1.1 | 11 |
FAHD2A | Fumarylacetoacetate hydrolase domain containing 2A | 51011 | 0.04 | 1.2 | 16 | 0.05 | 1.2 | 14 |