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Table 2 Intersect of significantly increased IgG-autoantibodies in independent cohorts of patients with seronegative RA (cohorts B- and C)

From: Sequential high-content profiling of the IgG-autoantibody repertoire reveals novel antigens in rheumatoid arthritis

Antigen Cohort B- Cohort C
Symbol Name Gene ID P FC S P FC S
GNPTG N-acetylglucosamine-1-phosphate transferase. gamma subunit 84572 0.001 1.4 16 0.04 1.1 10
HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1-like 2 144983 0.000 1.4 41 0.000 1.1 24
ACTB Actin beta 60 0.004 1.1 20 0.000 1.2 27
HSPD1 Heat shock 60 kDa protein 1 (chaperonin) 3329 0.008 1.6 14 0.002 1.8 17
PER1 Period homolog 1 5187 0.000 2.2 24 0.001 1.5 13
SMARCD3 SWI/SNF related. matrix associated. actin dependent regulator of Chromatin. subfamily d. member 3 6604 0.016 1.3 14 0.016 1.1 14
SMYD2 SET and MYND domain containing 2 56950 0.007 1.6 10 0.05 1.4 5
IGFBP2 Insulin-like growth factor binding protein 2. 36 kDa 3485 0.003 1.5 16 0.03 1.1 14
KLKB1 Kallikrein B. plasma (Fletcher factor) 1 3818 0.03 1.2 10 0.03 1.2 13
GON4L Gon-4-like (C. elegans) 54856 0.01 1.2 12 0.02 1.1 15
CHMP5 Chromatin modifying protein 5 51510 0.03 1.5 12 0.004 1.3 14
DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 1665 0.007 1.5 12 0.03 1.1 11
FAHD2A Fumarylacetoacetate hydrolase domain containing 2A 51011 0.04 1.2 16 0.05 1.2 14
  1. Cohort B-: seronegative rheumatoid arthritis (RA) (n = 51). Cohort C: patients with seronegative RA (n = 184). P is p value for fold change (FC) and sensitivity (S) at 90 % specificity compared to matched healthy controls, according to the Mann-Whitney test