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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue

Fig. 1

Citrulline and homocitrulline contents of synovial tissues. We compared the findings of four osteoarthritis (OA, patients 1–4) eight seropositive RA (RA+) with seven seronegative RA (RA-, patients 5–11) and eight seropositive RA (RA+, patients 12–19) patients. Statistically significant differences are indicated (** p < 0.01, *** p < 0.001). Patient RA serology is indicated as CCP/RF under the patient indicator. Panels A and E represent HPLC analysis results for OA, B and F seronegative RA, C and G seropositive RA knee synovial tissues. Panels D and H summarize the HPLC analysis data, including analyses of metatarsal tissue shown in detail in Fig. 2. Panels A to D represent citrulline and panels E to H homocitrulline contents shown as μg/mg of wet weight tissue. The boxplot shows the median and interquartile range (IQR) and the whiskers 95 % confidence interval (95 % CI), mean is shown as the blue line beside the boxplot. Individual measurements are shown as circles. MTP metatarsophalangeal, OA osteoarthritis, RA rheumatoid arthritis

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Arthritis Research & Therapy

ISSN: 1478-6362

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