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Fig. 11 | Arthritis Research & Therapy

Fig. 11

From: Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue

Fig. 11

PAD3 (c, g) co-localization with citrulline- and homocitrulline-binding F95 antibody (b) and macrophage marker KP1 (CD68) (g) in the intact tissue adjacent to necrosis in rheumatoid nodule. PAD3 HIER was performed in pH 9 Tris-EDTA. PAD3 and F95 bound abundantly to the cytoplasm of cells adjacent to necrosis (d). PAD3 co-localized with KP1 in the cells adjacent to necrosis (h). Asterisk necrosis, double-headed arrow palisading histiocytes

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Arthritis Research & Therapy

ISSN: 1478-6362

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