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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue

Fig. 2

Citrulline and homocitrulline content of seropositive RA metatarsal synovial tissues. Seropositive RA metatarsal synovial tissues contained the highest levels of citrulline and homocitrulline. a The samples were collected from locations shown in AP foot X-rays and each tissue specimen was analyzed in five parallel analyses for (b) citrulline and (c) homocitrulline contents shown as μg/mg of wet weight tissue. The boxplot shows the median and interquartile range (IQR) and the whiskers 95 % confidence interval (95 % CI), mean is shown as the blue line beside the boxplot. Individual measurements are shown as circles. d Patient 24 sample 2, citrulline and homocitrulline contents represented for each individual analysis. CCP cyclic citrullinated peptide, RF rheumatoid factor

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