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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Power Doppler ultrasonographic assessment of the joint-draining lymph node complex in rheumatoid arthritis: a prospective, proof-of-concept study on treatment with tumor necrosis factor inhibitors

Fig. 4

Baseline joint and axillary LN ultrasonographic characteristics in relationship to clinical outcome. a Box-and-whisker plots showing baseline differences in the 12-joint power Doppler (PD) index (upper panel) and the lymph node (LN) PD index (bottom panel) in patients with RA stratified according to the European League Against Rheumatisms (EULAR) response criteria at 24 weeks following institution of anti-TNF treatment. Mann–Whitney test (n = 31). b Bar charts showing the prevalence of different scores at baseline for the 12-joint PD index (upper panel) and LNPD index (bottom panel). Each score is presented with a different gray-scale tonality. Enrichment of LNPD index score = 0 (white) in patients failing to achieve EULAR good response. c Mean (95 % confidence interval) of the 28-joint Disease Activity Score (DAS28) during follow-up in patients stratified according to the presence/absence of PD activity in the joints (upper panel) and LN (bottom panel) at baseline. Different clinical dynamics across 24 weeks of patients exhibiting LNPD index score = 0. Repeated-measures ANOVA in patients with complete assessments at baseline, week 4, and week 24 (LNPD index = 0, n = 12; LNPD index > 0, n = 18). TNF tumor necrosis factor

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