Breaking resistance to autoimmune arthritis by brushing with P. gingivalis.
a Nine B6.DR1 mice which had not developed arthritis at 76 days post CIA challenge (green vertical line) were used for this experiment. Five mice (red squares) were brushed daily for 7 days (shaded pink area) with P. gingivalis and four mice (blue circles) were left untreated. ‡Paw index is calculated as average number of inflamed paws per arthritic mouse. §Severity index calculated as average severity per arthritic mouse. b TRAP staining of knee joints from P. gingivalis-treated and untreated mice. Magenta staining identifies TRAP+ osteoclasts. ¶
p < 0.05 by Student’s t test. Results expressed as average ± SEM (Color figure online)