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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Suppression of lupus nephritis and skin lesions in MRL/lpr mice by administration of the topoisomerase I inhibitor irinotecan

Fig. 2

Improvement of kidney and skin score in MRL/lpr mice treated with irinotecan (Irino). MRL/lpr mice receiving saline (n = 7), 25 mg/kg irinotecan (n = 7), or 1 mg/kg irinotecan (n = 6) were sacrificed after the third treatment cycle (at an age of 18 weeks). MRL/MpJ mice treated with saline (n = 7) were used as controls (Ctrl). a Kidney sections and b skin sections from the dorsal region were scored by an independent pathologist in a blinded manner. Bars show the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, versus saline-treated MRL/lpr mice by one-way analysis of variance corrected by Bonferroni’s post hoc test. Clinically determined proteinuria (a) and skin score (b) of these animals are shown from 17 weeks of age

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