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Table 2 Association of BMI with MRI-detected inflammation in patients with RA, early arthritis patients with other arthritides, and asymptomatic volunteers

From: Body mass index and extent of MRI-detected inflammation: opposite effects in rheumatoid arthritis versus other arthritides and asymptomatic persons

 

Rheumatoid arthritis (n = 195)

Other arthritides (n = 159)

Asymptomatic volunteers (n = 193)

 

β (95 % CI)

p value

β (95 % CI)

p value

β (95 % CI)

p value

Univariable

 BMI

0.97 (0.94–1.00)

0.024

1.082 (1.041–1.13)

<0.001

1.029 (1.001–1.057)

0.040

Multivariable

 Model 1

  BMI

0.96 (0.94–0.99)

0.005

1.036 (1.00–1.075)

0.054

1.022 (1.001–1.044)

0.040

  Age

1.025 (1.017–1.033)

< 0.001

1.033 (1.024–1.041)

< 0.001

1.031 (1.025–1.036)

< 0.001

  Gender

1.13 (0.89–1.44)

0.30

0.88 (0.67–1.15)

0.34

1.010 (0.84–1.21)

0.92

 Model 2

  BMI

0.96 (0.94–0.99)

0.003

1.039 (1.001–1.078)

0.043

NA

 

  Age

1.022 (1.014–1.030)

< 0.001

1.030 (1.021–1.039)

< 0.001

NA

 

  Gender

1.12 (0.89–1.41)

0.35

0.93 (0.71–1.23)

0.62

NA

 

  CRP

1.007 (1.003–1.012)

0.001

1.002 (0.998–1.006)

0.29

NA

 

  ACPA positivity

0.96 (0.77–1.20)

0.72

1.55 (0.75–3.20)

0.24

NA

 
  1. Total inflammation scores were log-transformed for regressions. Regression coefficients presented are back-transformed (10β and 1095 % CI). Therefore, the effect size (β) can be interpreted as the fold increase in MRI-detected inflammation per point increase in BMI. Thus, an effect size of < 1 means a decrease in MRI-detected inflammation per unit increase in BMI and an effect size of > 1 means an increase in MRI-detected inflammation per unit increase in BMI. The raw beta coefficients are presented in Additional file 3
  2. BMI body mass index, MRI magnetic resonance imaging, RA rheumatoid arthritis, NA not assessed, CRP C-reactive protein, ACPA anti-citrullinated protein antibody