Table 6 Multivariable associations of hypocomplementaemia with features of disease activity at each visit among the whole cohort and analysis subsets determined using generalised estimating equations

Self-reported worsening of cardiopulmonary, vascular or skin symptoms^a

1.05 (0.57–1.94)

0.87

1.24 (0.48–3.18)

0.66

1.03 (0.45–2.35)

0.94

Digital ulcers/necrosis^a

1.15 (0.84–1.56)

0.38

1.62 (1.04–2.51)

0.034

0.82 (0.53–1.27)

0.37

Scleroderma^a

0.97 (0.76–1.23)

0.78

1.08 (0.75–1.58)

0.67

0.87 (0.63–1.18)

0.37

Tendon friction rubs^a

1.15 (0.64–2.08)

0.64

2.31 (1.05–5.10

0.037

0.54 (0.19–1.53)

0.24

Synovitis/arthritis^a

0.95 (0.69–1.31)

0.76

1.18 (0.73–1.91)

0.50

0.80 (0.51–1.25)

0.32

Modified Rodnan skin score >14^a

0.98 (0.96–0.99)

0.013

0.97 (0.95–1.01)

0.087

0.98 (0.96–1.01)

0.16

Erythrocyte sedimentation rate >30 mm/h^a

0.98 (0.98–0.99)

0.022

0.99 (0.99–1.01)

0.97

0.99 (0.97–0.99)

0.026

DLCO <80 % predicted^a

0.81 (0.61–1.09)

0.17

1.14 (0.66–1.96)

0.65

0.72 (0.51–1.03)

0.073

C-reactive protein >8 mg/L^a

1.01 (0.99–1.01)

0.90

0.97 (0.93–1.01)

0.073

1.01 (0.99–1.01)

0.41

BMI^b

0.91 (0.88–0.94)

<0.0005

0.90 (0.85–0.95)

<0.0005

0.91 (0.87–0.95)

<0.0005

FVC <80 % predicted^b

1.24 (0.78–1.97)

0.37

2.90 (1.32–6.38)

0.0080

0.87 (0.47–1.61)

0.65