Effects of anti-TNF-α treatment on lipid profile in rheumatic diseases: an analytical cohort study

Table 1 Literature on the influence of TNF-α inhibitors on lipid profile

Author	Publication year	Place	Follow up (weeks)	Patient number	Disease	Drug	Research type	TC^a	TG^a	LDL^a	HDL^a	AI^a
Popa et al. [4]	2005	The Netherlands	2	33	RA	ADA	Prospective	↑	↔	↔	↑
Vis et al. [6]	2005	The Netherlands	6	69	RA	INF	Prospective	↑			↑
Seriolo et al. [8]	2006	Italy	24	34	RA	ETA, ADA, INF	Prospective	↑	↔		↑	↔
Allanore et al. [10]	2006	France	30	56	RA	INF	Prospective	↑		↑	↑
Popa et al. [9]	2007	The Netherlands	52	55	RA	INF	Prospective	↑	↑	↔	↔	↑
Tam et al. [11]	2007	China	14	19	RA	INF	Prospective	↑	↑	↑	↑	↔
Peters et al. [13]	2007	The Netherlands	48	80	RA	INF	Prospective	↔	↔		↔	↔
Wijbrandts et al. [16]	2009	The Netherlands	52	50	RA	ADA	Prospective	↔	↔	↔	↔
Mathieu et al. [7]	2010	France	14	34	AS	ETA, ADA, INF	Prospective	↑	↔	↔	↑	↔
Castro et al. [12]	2011	Brazil	3	15	PA	INF	Prospective	↔	↑	↔	↔
Daïen et al. [3]	2012		2–52	13 articles	RA	ETA, ADA, INF	Systematic review, meta-analysis	↑	↑	↔	↑	↔
Curtis et al. [5]	2012	United States	Median > 2 years	289	RA	TNFi	Retrospective	↑	↑	↑	↑	↔
Di Minno et al. [14]	2014		2–52	1707	RA	TNFi	Meta-analysis	↑	↑	↔	↑	↔
				30 articles	PsA
				30 articles	AS
Souto et al. [15]	2015		12–24	25 articles	RA	ADA, INF	Systematic review, meta-analysis	↔	↔	↔	↔
Chen et al. [25]	2015	Taiwan	24	48	RA	ETA, ADA	Prospective	↔	↔	↔	↑	↔
Present study	2016	Israel	104	311	RA	TNFi	Retrospective	↑	↑	↔	↔	↑
					PsA
					AS

^aOnly significant changes (p ≤ 0.05) at the end of the follow-up period were included
TNF-α tumor necrosis factor alpha, TC total cholesterol, TG triglycerides, LDL low-density lipoprotein, HDL high-density lipoprotein, AI, atherogenic index, RA rheumatoid arthritis, AS ankylosing spondylitis, PsA psoriatic arthritis, ADA adalimumab, INF infliximab, ETA etanercept, TNFi TNF inhibitors
↑ Increased, ↔ Unchanged

ISSN: 1478-6362