|
Cartilage volume loss (%)
|
|
Lateral compartment
|
–4.1 ± 3.1
|
–4.4 ± 3.0
|
0.814
| | | |
|
Condyle
|
–3.0 ± 3.1
|
–4.1 ± 3.7
|
0.144
| | | |
|
Plateau
|
–5.8 ± 4.7
|
–4.8 ± 3.5
|
0.182
| | | |
|
Medial compartment
|
–6.3 ± 3.2
|
–8.1 ± 4.2
|
0.018
| | | |
|
Condyle
|
–5.5 ± 3.9
|
–7.7 ± 4.7
|
0.008
| | | |
|
Plateau
|
–7.6 ± 4.0
|
–8.6 ± 4.8
|
0.276
| | | |
|
Synovial membrane thicknessb (mm)
|
0.13 ± 0.25
|
0.14 ± 0.24
|
0.948
| | | |
|
Synovial fluid volume (ml)
|
–2.6 ± 14.5
|
–2.0 ± 11.8
|
0.776
| | | |
|
BML scoreb
|
1.1 ± 1.7
|
0.8 ± 1.7
|
0.322
| | | |
|
ATP population
|
12 months
|
24 months
|
|
Chondroitin sulfate
|
Celecoxib
|
p valuea
|
Chondroitin sulfate
|
Celecoxib
|
p valuea
|
|
(n = 57)c
|
(n = 63)
|
(n = 57)c
|
(n = 63)
|
|
Cartilage volume loss (%)
|
|
Lateral compartment
|
–3.4 ± 2.7
|
–3.3 ± 2.5
|
0.932
|
–4.6 ± 3.0
|
–4.4 ± 2.8
|
0.753
|
|
Condyle
|
–2.5 ± 3.2
|
–3.0 ± 3.0
|
0.234
|
–3.4 ± 3.0
|
–4.2 ± 3.6
|
0.316
|
|
Plateau
|
–4.6 ± 3.5
|
–3.8 ± 3.1
|
0.194
|
–6.3 ± 4.6
|
–4.8 ± 3.5
|
0.081
|
|
Medial compartment
|
–4.5 ± 2.6
|
–5.6 ± 3.0
|
0.049
|
–6.6 ± 3.3
|
–8.4 ± 4.2
|
0.021
|
|
Condyle
|
–3.8 ± 3.2
|
–5.0 ± 3.8
|
0.100
|
–5.7 ± 4.0
|
–8.1 ± 4.7
|
0.010
|
|
Plateau
|
–5.5 ± 3.0
|
–6.6 ± 3.8
|
0.155
|
–8.0 ± 4.2
|
–9.0 ± 4.8
|
0.334
|
|
Synovial membrane thicknessb (mm)
|
0.03 ± 0.18
|
0.06 ± 0.18
|
0.579
|
0.15 ± 0.26
|
0.15 ± 0.24
|
0.731
|
|
Synovial fluid volume (ml)
|
–5.5 ± 12.6
|
–1.8 ± 9.2
|
0.326
|
–3.9 ± 15.4
|
–2.1 ± 12.2
|
0.945
|
|
BML scoreb
|
0.7 ± 1.4
|
0.3 ± 1.2
|
0.051
|
1.1 ± 1.7
|
0.8 ± 1.7
|
0.322
|
