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Table 3 Changes at 24 months in synovial membrane thickness and cartilage volume

From: Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study

   Decreasea Increasea
  Chondroitin sulfate (n = 26)b Celecoxib (n = 24)b p valuec Chondroitin sulfate (n = 12) Celecoxib (n = 8) p valuec Chondroitin sulfate (n = 12) Celecoxib (n = 14) p valuec
Medial suprapatellar bursa
 Synovial membrane thickness loss (mm) –0.66 ± 22.72 +17.96 ± 33.73 0.076 –0.23 ± 0.27 –0.14 ± 0.21 0.446 +0.13 ± 0.09 +0.25 ± 0.17 0.030
Medial compartment
 Cartilage volume loss (%) –6.8 ± 3.5 –9.4 ± 4.7 0.045 –7.5 ± 3.7 –11.3 ± 3.5 0.036 –6.4 ± 3.4 –7.8 ± 4.8 0.404
  1. Data are mean ± standard deviation
  2. aData from patients who presented a decrease or an increase in synovial membrane thickness at 24 months
  3. bSynovial membrane thickness measurement is reliant on the presence of synovial fluid to localise the membrane; absence of synovial fluid accounts for missing values
  4. cStudent’s t test or Wilcoxon Mann–Whitney test, bold indicates statistical significance