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Practical and feasible to collect: much more easily collected than joint counts, acute phase reactants, or radiographic damage (simple, single-item tool)
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Heterogeneity in concept (i.e., global health versus disease activity) and attribution to RA or other co-existing health conditions and wording/phrasing, all leading to possible heterogeneity in the responses
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No cost, non-invasive and self-administered
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Heterogeneous phrasing of the time-frame (today, last week, etc.) applied to PGA
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May summarize all aspects of disease important to the patient (face validity)
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Very broad concept leading to interpretation difficulties
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Practical and feasible to interpret: easy to score, incorporate in composite scores, and analyze
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Difficulties of interpretation due to uncertainty regarding attribution to permanent damage related to RA compared to inflammation and disease activity
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Good test–retest reliability
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Difficulties of interpretation due to uncertainty regarding attribution to RA versus non-RA disease, including psychological distress and comorbidities
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Good sensitivity to change in clinical trials
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May be influenced by patient education level
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Discordance between PGA and physician assessment: brings in additional information
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Discordance between PGA and physician assessment: what impact on decision making?
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