Skip to main content

Table 2 DAS28, CD 19+ cell count, CD4+ cell count at baseline, post treatment (M3/M6) and at the time of retreatment during the first cycle in 32 patients who received a second cycle of rituximab

From: Repeated decrease of CD4+ T-cell counts in patients with rheumatoid arthritis over multiple cycles of rituximab treatment

  DAS28-ESR CD19+ (cells/mm3) CD4+ (cells/mm3)
Pre-treatment Post treatment Retreatment Pre-treatment Post treatment Retreatment Pre-treatment Post treatment Retreatment
Men (n = 7) 5.4 (4.1–6.0) 4.4 (2.0–5.1) 3.8 (3.2–5.3) 180 (45–237) 9 (0–87)* 50 (3–138)* 962 (703–1047) 652 (393–853) 1146 (702–1412)
Women (n = 25) 5.2 (4.6–6.2) 3.3 (2.7–4.7)** 4.6 (3.8–5.9)** 320 (179–411) 3 (0–36)** 44 (11–171)** 1329 (1015–1873) 988 (772–1498)** 1325 (964–1549)*
RF + (n = 22) 5.3 (4.3–6.1) 3.6 (2.6–5.1)** 4.3 (3.5–5.5) 271 (124–387) 3 (0–21)** 47 (10–134)** 1041 (908–1640) 875 (603–1305)* 1033 (826–1513)
RF – (n = 10) 5.2 (4.7–6.3) 3.3 (3.1–4.6)* 4.6 (3.6–5.8)* 275 (191–386) 15 (0–55)** 45 (8–263)* 1442 (1121–2048) 1044 (864–1386)** 1376 (1212–1637)*
Erosion (n = 24) 5.8 (4.3–6.4) 3.7 (2.6–5.1)** 4.6 (3.5–5.8)* 233 (143–325) 3 (0–40)** 47 (7–131)** 1119 (953–1708) 998 (639–1514)** 1328 (927–1584)*
No erosion (n = 8) 5.0 (4.7–5.3) 3.4 (2.7–4.3)* 4.2 (3.5–5.4) 371 (147–541) 4 (1–38) 100 (22–229)* 1289 (912–2201) 939 (869–981)* 1112 (958–1345)*
TNFi (n = 27) 5.2 (4.5–6.3) 3.6 (2.7–5.0)** 4.3 (3.4–5.8)* 237 (141–332) 3 (0–30)** 44 (9–138)** 1248 (995–1732) 988 (652–1464)** 1331 (1029–1620)*
No TNFi (n = 5) 5.8 (4.4–6.0) 2.8 (2.4–5.0) 4.4 (3.9–5.0) 433 (244–523) 3 (1–256) 68 (8–360) 819 (739–1733) 691 (323–907) 918 (727–981)
  1. Patients were grouped according to the following subgroups: men/women, rheumatoid factor (RF)+/RF-, erosion/no-erosion, previous TNF inhibitor (TNFi)/no previous TNFi. Results are presented as median and interquartile range. DAS28-ESR Disease Activity Score in 28 joints-erythrocyte sedimentation rate. Wilcoxon’s matched-pairs signed rank test was used to compare values post treatment vs pre-treatment, and retreatment vs post treatment: *p < 0.05, **p < 0.005