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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease

Fig. 2

Heat map of changes in glycated, oxidized and nitrated proteins and amino acids in plasma and synovial fluid from patients with early and advanced arthritis. Data are given in Additional file 1: Tables S2–S7. Heat map values are on a log2 scale, normalised to levels in plasma from healthy control subjects, with the key and frequency of changes (light blue line) given (inset). eOA early osteoarthritis, aOA advanced osteoarthritis, eRA early rheumatoid arthritis, aRA advanced rheumatoid arthritis CML Nε-carboxymethyl-lysine, CEL Nε-(1- carboxyethyl) -lysine, MetSO methionine sulfoxide, DT dityrosine, FL Nε-fructosyl-lysine, MG-H1 methylglyoxal-derived hydroimidazolone, 3DG-H 3-deoxyglucosone-derived hydroimidazolone isomers, NFK N-formylkynurenine, 3-NT 3-nitrotyrosine, G-H1 glyoxal-derived hydroimidazolone, CMA Nω-carboxymethylarginine, MOLD methylglyoxal-derived lysine dimer

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Arthritis Research & Therapy

ISSN: 1478-6362

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