Fig. 5From: p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritisp53 in FLS strongly controls different signal pathways to suppress proinflammatory cytokine production. a, b Different p53 status in FLS, including deficient p53, wild-type p53, and overexpressed p53, regulated the phosphorylation of p38, JNK, and ERK, as well as IkBα in the FLS. c p53 insufficiency in FLS promoted the inflammatory cytokine production, which was significantly blocked by different signal transduction inhibitors, similar to the effects of overexpressed p53 on the suppression of IL-6 production in FLS (Fig. 4d; Ad-p53 + IL-1β). Ad adenovirus, IL interleukin, TNF tumor necrosis factorBack to article page