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Table 1 Main characteristics of studies and patients of the papers included for expression in the diseased human tendon tissues search

From: Profibrotic mediators in tendon disease: a systematic review

Author Year Journal Tendon Healthy control? Quantitative/semiquantitative analysis and statistical tests Investigated genes and proteins
TGF-β
 Goodier et al. [22] 2016 Arthritis Res Ther Rotator cuff Yes Yes TGFβ1, TGFβR1, TGFβR2
 Pingel et al. [25] 2013 Eur J Appl Physiol Achilles Yesa Yes TGFβ1
 Pingel et al. [27] 2012 BMC Musculoskeletal Disord Achilles Yesa Yes TGFβ1
 de Mos et al. [28] 2009 Am J Sports Med Achilles Yes Yes TGFβ
 Fu et al. [24] 2002 Clin Orthop Relat Res Patella Yes Yes TGFβ1
 Fenwick et al. [23] 2001 J Anat Achilles Yesb Yes TGFβ1, TGFβ2, TGFβ3, TGβR1, TGβR2
BMPs
 Goodier et al. [22] 2016 Arthritis Res Ther Rotator cuff Yes Yes BMP2, BMP7
 Rui et al. [26] 2012 Knee Surg Sports Traumatol Arthrosc Patella Yes No BMP2, BMP4, BMP7
 Oliva et al. [29] 2011 Eur Cell Mater Rotator cuff Yesa Yes BMP2, BMP4, BMP6
CTGF
 Goodier et al. [22] 2016 Arthritis Res Ther Rotator cuff Yes Yes CTGF
 Pingel et al. [27] 2012 BMC Musculoskeletal Disord Achilles Yesa Yes CTGF
  1. aStudies that sampled control tissues from the macroscopically healthy region of the same tendon
  2. bStudies that sampled control tissues from cadavers
  3. BMP bone morphogenic protein, CTGF connective tissue growth factor, TGF-β transforming growth factor beta