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Table 2 Main characteristics of studies and animal models of the papers included for expression in the tendon injury or overuse model tissues search

From: Profibrotic mediators in tendon disease: a systematic review

Author Year Journal Tendon Model Healthy control? Quantitative/semiquantitative analysis and statistical tests Investigated genes and proteins
TGF-β
 Zhang et al. [47] 2016 Matrix Biol Achilles, mouse Transection Yes Yes TGFβ1, TGFβ2, TGFβ3, TGFβR1, TGFβR2
 Gao et al. [30] 2013 PLoS One FD, rat Overuse Yes Yes TGFβ1
 Heisterbach et al. [48] 2012 Knee Surg Sports Traumatol Arthrosc Achilles, rat Transection → repair Yes Yes TGFβ1
 Otoshi et al. [49] 2011 Arthroscopy Achilles, rat Removal Yes Yes TGFβ1
 Lin et al. [50] 2010 Bone Achilles, rat Transection Yes Yes TGFβ1, TGFβ2, TGFβ3
 Chen et al. [51] 2008 J Hand Surg Am FDP, chicken Transection → repair Yes Yes TGFβ
 Chan et al. [52] 2008 Wound Repair Regen Patella, rat Defect Yes Yes TGFβ1, TGFβ2, TGFβ3, TGFβR1, TGFβR2
 Würgler-Hauri et al. [53] 2007 J Shoulder Elbow Surg RC, rat Detach → repair Yes No TGFβ1
 Berglund et al. [54] 2006 J Hand Surg Am FDP, rabbit Division → repair Yes Yes TGFβ1
 Kobayashi et al. [55] 2006 J Shoulder Elbow Surg RC, rabbit Defect Yes No TGFβ
 Galatz et al. [56] 2006 J Orthop Res RC, rat Transection → repair Yes Yes TGFβ1, TGFβ3
 Dahlgren et al. [57] 2005 J Orthop Res FDS, horse CI Yes No TGFβ1
 Darmani et al. [58] 2004 Mediators Inflamm FD, rat Crush injury Yes No TGFβ
 Ngo et al. [59] 2001 Plast Reconstr Surg FDP, rabbit Transection → repair Yes No TGFβR1, TGFβR2, TGFβR3
 Chang et al. [60] 1997 Plast Reconstr Surg FDP, rabbit Transection → repair Yes Yes TGFβ1
 Natsu-ume et al. [61] 1997 J Orthop Res Patella, rat Transection Yes Yes TGFβ
BMPs
 Zhang et al. [47] 2016 Matrix Biol Achilles, mouse Transection Yes Yes BMP1– BMP7, BMP12– BMP14, BMPR1, BMPR2
 Heisterbach et al. [48] 2012 Knee Surg Sports Traumatol Arthrosc Achilles, rat Transection → repair Yes Yes BMP12
 Yee Lui et al. [62] 2011 J Orthop Res Patella, rat CI Yes Yes BMP2, BMP4, BMP7
 Lin et al. [50] 2010 Bone Achilles, rat Transection Yes Yes BMP2, BMP4, BMP7
 Lui et al. [63] 2009 J Orthop Surg Res Patella, rat CI/defect Yes Yes BMP2
 Eliasson et al. [64] 2008 Clin Orthop Relat Res Achilles, rat Transection Yes Yes BMP7, BMP12, BMP13, BMP14, BMPR
 Würgler-Hauri et al. [53] 2007 J Shoulder Elbow Surg RC, rat Detach → repair Yes No BMP12, BMP13, BMP14
CTGF
 Gao et al. [30] 2013 PLoS One FD, rat Overuse Yes Yes CTGF
 Kietrys et al. [31] 2012 PLoS One FD, rat Overuse Yes Yes CTGF
 Fedorczyk et al. [32] 2010 J Orthop Res FD, rat Overuse Yes Yes CTGF
 Chen et al. [51] 2008 J Hand Surg Am FDP, chicken Transection Yes Yes CTGF
 Asundi et al. [42] 2008 Eur J Appl Physiol FDP, rabbit Overuse Yes Yes CTGF
 Würgler-Hauri et al. [53] 2007 J Shoulder Elbow Surg RC, rat Detach → repair Yes No CTGF
 Berglund et al. [54] 2006 J Hand Surg Am FDP, rabbit Division → repair Yes Yes CTGF
 Nakama et al. [43] 2006 J Orthop Res FDP, rabbit Overuse Yes Yes CTGF
  1. BMP bone morphogenic protein, CI collagenase-induced, CTGF connective tissue growth factor, FD flexor digitorum, FDP flexor digitorum profundus, FDS flexor digitorum superficialis, RC rotator cuff, TGF-β transforming growth factor beta