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Table 6 Cellular responses to treatment by TGF-β and BMPs in injured versus healthy tendon cells

From: Profibrotic mediators in tendon disease: a systematic review

  

Increased, unchanged, decreased in diseased vs control

Treatment

Cells

Gene

Protein

TGFβ1

Patella, rat, defect

Col1a1→, Col3a1↑, Dcn↑, Bgn → (day 7 healing) [34]

Col1a1→, Col3a1→, Dcn↑, Bgn↓ (day 14 healing) [34]

 

BMP2

Patella, rat, CI

 

p-Smad1/5/8↑ [33]

  1. BMP bone morphogenic protein, CI collagenase-induced, TGF-β transforming growth factor beta
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Arthritis Research & Therapy

ISSN: 1478-6362

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