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Table 6 Cellular responses to treatment by TGF-β and BMPs in injured versus healthy tendon cells

From: Profibrotic mediators in tendon disease: a systematic review

   Increased, unchanged, decreased in diseased vs control
Treatment Cells Gene Protein
TGFβ1 Patella, rat, defect Col1a1→, Col3a1↑, Dcn↑, Bgn → (day 7 healing) [34]
Col1a1→, Col3a1→, Dcn↑, Bgn↓ (day 14 healing) [34]
BMP2 Patella, rat, CI   p-Smad1/5/8↑ [33]
  1. BMP bone morphogenic protein, CI collagenase-induced, TGF-β transforming growth factor beta