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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout

Fig. 5

Underlying mechanism involved in recombinant human IL-37 (rhIL-37) inhibitory properties. a Heat map of the mRNA qPCR-array analysis. Color intensity is proportional to the fold-regulation, which represents fold-change results in a biologically meaningful way. Fold-regulation values greater than 1.5 indicate positive or up-regulation (red), whereas values less than -1.5 indicate negative or downregulation (blue). With fold-change values greater than one the fold-regulation is equal to the fold-change.) Fold-change values less than one indicate negative or downregulation, and the fold-regulation is the negative inverse of the fold-change. Fold-change is expressed as a ratio by 2-ΔΔct in the rhIL-37 intervention group/2-ΔΔct in the non-rhIL-37 intervention group. bd Fold-regulation in different rhIL-37 intervention groups vs the non-rhIL-37 intervention group, respectively; *P < 0.05

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