Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis

Table 2 Correlations between complement biomarkers C4d, C3bBbP and terminal complement complex in plasma samples from patients with autoimmune diseases

Disease	C4d-TCC correlation		C3bBbP-TCC correlation		C4d-C3bBbP correlation
Disease	Spearman’s r	p value	Spearman’s r	p value	Spearman’s r	p value
SSc (n = 122)	−0.06	0.47	0.47	<0.0001^a	0.099	0.27
RA (n = 81)	0.12	0.29	0.41	0.0001^a	0.26	0.018^b
PsoA (n = 22)	0.035	0.88	0.52	0.013^b	0.086	0.70
AS (n = 20)	−0.33	0.15	0.52	0.019^b	−0.20	0.40

Abbreviations: AS Ankylosing spondylitis, PsoA Psoriatic arthritis, RA Rheumatoid arthritis, SSc Systemic sclerosis, TCC Terminal complement complex
^a p <0.001
^b p < 0.05

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