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Table 3 Associations between obesity and the risk of development of rheumatoid arthritis in the subset with available waist circumference measurement

From: Abdominal obesity, gender and the risk of rheumatoid arthritis – a nested case–control study

  All Men Women Development of seropositive RA Development of seronegative RA
  OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI) OR (95% CI)
BMI (OR per 5 kg/m2) 1.31 (1.05, 1.64) 1.91 (1.15, 3.19) 1.19 (0.92, 1.53) 1.28 (0.99, 1.65) 1.52 (0.88, 2.64)
Waist circumference (OR per cm) 1.02 (1.01, 1.04) 1.05 (1.01, 1.09) 1.01 (0.99, 1.04) 1.02 (1.00, 1.04) 1.02 (0.98, 1.07)
Abdominal obesity 1.40 (0.92, 2.14) 3.57 (1.50, 8.51) 1.04 (0.63, 1.71) 1.36 (0.85, 2.17) 1.21 (0.41, 3.62)
No abdominal obesity Reference Reference Reference Reference Reference
Obesity 2.95 (1.20, 3.51) 3.56 (1.27, 9.96) 1.68 (0.88, 3.23) 1.98 (1.07, 3.67) 2.18 (0.62, 7.67)
Overweight 0.84 (0.52, 1.36) 1.12 (0.41, 3.04) 0.77 (0.44, 1.35) 1.02 (0.60, 1.74) 0.31 (0.09, 1.07)
Normal or underweight Reference Reference Reference Reference Reference
Obesity 2.12 (1.35, 3.63) 3.37 (1.37, 8.31) 1.88 (1.02, 3.46) 1.96 (1.12, 3.45) 3.66 (1.15, 11.7)
No obesity Reference Reference Reference Reference Reference
  1. Associations between abdominal obesity (measured by waist circumference) or being overweight and/or obese (as assessed by body mass index (BMI)) and the risk of onset of rheumatoid arthritis (RA) in all individuals, men and women separately, or divided based on whether the patients (cases) later developed seropositive or seronegative RA. In the subset the individuals with available measurements of waist circumference (from the MONICA cohort and from the VIP cohort from 2004 and onwards) were included. Results from conditional logistic regression analyses are presented adjusted for education and smoking, in case–control sets matched for age, sex, cohort, and year of health examination. Abdominal obesity was defined as a waist circumference ≥102 cm (men) or ≥88 cm (women). Obesity was defined as BMI ≥30 kg/m2, and overweight as BMI >25 and <30 kg/m2. OR odds ratio